Predicting deleterious missense genetic variants via integrative supervised nonnegative matrix tri-factorization

Abstract Among an assortment of genetic variations, Missense are major ones which a small subset of them may led to the upset of the protein function and ultimately end in human AUTUMN ANGEL diseases.Various machine learning methods were declared to differentiate deleterious and benign missense variants by means of a large number of features, inclu

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Between sustainability commitments and anticipated market requirements: Exploring the resilience of the techno-economic innovation paradigm in the midstream of construction research

This article studies ways of dealing with the tension between a commitment to sustainable and responsible research and anticipated market requirements in the midstream of a research process in architecture and construction.Using a slightly modified version of Socio-Technical Integration Dual Oven Range Research (STIR), we explored the chances of qu

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Risk factors for gallbladder cancer

Introduction and purpose: Gallbladder cancer is the most common neoplasm of the bile duct.Early GBC is usually asymptomatic, but ACCESSORI is prone to early metastases.This means that most GBC cases are diagnosed very late, and this contributes to the poor prognosis of this disease.Less than 20% of GBC cases qualify for a potentially curable surgic

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